I like to call it the Kansas problem. This is the issue that many young scientists (and older scientists!) face many times in their careers. The best offer, the best money, the best options...in a terrible location. The problem I like to call "If you don't move to Kansas you will ruin your career". And it's an issue I'd like to discuss over at Scientopia today! So head over, check it out, and let me know what you think.
NOTE: I, in fact, have nothing against Kansas. It's just often the first thing that springs to mind when I think of places filled with grain, grain, and...grain.