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Molecules to Medicine

Molecules to Medicine

Demystifying drug development, clinical research, medicine, and the role ethics plays

Drug screens-any more than theater?

I’ve been doing a lot of traveling recently, and am increasingly disturbed by the growing surveillance society and the misplaced reassurances that are used to assuage the public, coined “security theater” by Bruce Schneier...

February 19, 2013 — Judy Stone

Prosecutorial Excess: A Pattern of Abuse

I continue on break from the UMN Markingson story as I try to make sense—although there appears none to be had—of the tragic death of Aaron Swartz. I am haunted and infuriated by the senselessness of his death and his persecution by overzealous prosecutors...

January 24, 2013 — Judy Stone

An Elegy for Aaron

This post is in honor of Aaron Swartz. I had long considered posting my book as open access but had hesitated in doing so, even though I have long been an enthusiast about OLPC and Creative Commons...

January 14, 2013 — Judy Stone

A Clinical Trial and Suicide Leave Many Questions: Part 3: Conflict of Interest

We’ve touched on some of the many disturbing things that happened during the clinical trial on which Dan Markingson committed suicide. In my first post, I asked how a psychotic, homicidal patient who was involuntarily hospitalized in a psychiatric hospital could give an informed consent for participation in a clinical trial...

December 18, 2012 — Judy Stone

A Clinical Trial and Suicide Leave Many Questions: Part 2: Investigator Responsibilities

There are many disturbing things that happened during the clinical trial on which Dan Markingson committed suicide. Besides the issue of consent, or lack thereof, which I raised in my last post, one of the most disturbing aspects to me has been the lack of accountability and the apparent violations of clinical practice standards, with no consequences. Zero accountability is how I have come to understand the outcome of this CAFÉ trial. Clinical Research Standards—in TheoryDespite sensationalistic trials gone wrong, there are actually principles for “Good Clinical Practice,” and numerous guidelines for the ethical conduct of clinical trials...

December 13, 2012 — Judy Stone

A Clinical Trial and Suicide Leave Many Questions: Part 1: Consent?

 The suicide of Dan Markingson, a 26 year old man participating in a psychiatric trial, has again made the news, and will serve us for a life-time of study and discussion of research ethics, along with the TeGenero and Jesse Gelsinger cases. Markingson began to show signs of paranoia and delusions in 2003, believing that he needed to murder his mother...

December 11, 2012 — Judy Stone

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Scientific American Health & Medicine

Scientific American Health & Medicine