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Fat Tuesday: Caloric restriction s days are numbered

This article was published in Scientific American’s former blog network and reflects the views of the author, not necessarily those of Scientific American



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(Ed. note: this blog was previously posted on sleightsofmind.com)

“The only way to keep your health is to eat what you don’t want, drink what you don’t like, and do what you’d rather not.” – Mark Twain

Twain may have been correct about health, but longevity may be another matter altogether. Eat, drink, and be merry… if you want to die: that is what the evidence has shown for the last 75 years, right? In a way, perhaps it was too good to be true: go on a diet and live happily ever after… forever. Well, not forever, but, yes, for significantly longer. It still seems to be a robust finding in mice and rats, where lifetimes are short and easily measured in the lifetime of a single grant funding cycle. But a recent careful, well-controlled, and decade-spanning study from a group at the National Institute on Aging has shown that, whereas monkeys that are put on a restricted diet long-term may be healthier than monkeys that are fed 50% more, they don’t live longer. But you have to admit, the monkeys do look spritely.

Nature 489, 318–321 (13 September 2012) doi:10.1038/nature11432

https://www.nature.com.ezproxy1.lib.asu.edu/nature/journal/vaop/ncurrent/pdf/nature11484.pdf

 

Stephen L. Macknik is a professor of opthalmology, neurology, and physiology and pharmacology at SUNY Downstate Medical Center in Brooklyn, N.Y. Along with Susana Martinez-Conde and Sandra Blakeslee, he is author of the Prisma Prize-winning Sleights of Mind. Their forthcoming book, Champions of Illusion, will be published by Scientific American/Farrar, Straus and Giroux.

More by Stephen L. Macknik