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The Search for a Nobel Prize-Winning Synapse Machine

In the cellular machinery that Rothman, Schekman and Südhof all helped reconstruct, a SNARE complex - made of synaptobrevin, syntaxin and SNAP-25 - zips together to bind a synaptic vesicle to the surface of a receiving neuron. Courtesy of Danko Dimchev Georgiev, M.D. via Wikimedia Commons.

2013’s Nobel prize in Physiology or Medicine honors three researchers in particular – but what it really honors is thirty-plus years of work not only from them, but also from their labs, their graduate students and their collaborators. Winners James Rothman, Randy Schekman and Thomas Südhof all helped assemble our current picture of the cellular [...]

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Researchers Win Nobel for Cell Transport System

This year’s Nobel Prize in medicine or physiology was—true to the often-overlooked second half of its name—awarded for discoveries in basic physiology. The 2013 prize recognizes ground-breaking research into how cells use simple bubbles of fatty molecules (known as vesicles [pdf]) to safely transport proteins and hormones from one compartment to another within cells as [...]

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