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Eternal Sunshine Drug Points the Way Toward Counteracting the Agony of Chronic Pain

This article was published in Scientific American’s former blog network and reflects the views of the author, not necessarily those of Scientific American


One of brain researchers' closest brushes with science fiction in the last 10 years came with the discovery of a chemical that could completely wipe out memory, a molecule that evoked a real-life version of the scenario depicted in the film Eternal Sunshine of the Spotless Mind, in which a couple undertakes a procedure to erase their memory of each other when the relationship falls apart.

Fortunately, the artificial amnesia occurred only in laboratory rats. But the experiment raised an obvious question: What would anyone do with a drug that essentially reformats your mental hard drive?

Who would be interested besides a neurotic Woody Allen trying to reboot his life, or a sadistic Josef Mengele type attempting to conduct the kind of scientific experiment that would be judged a war crime at The Hague?


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A group of researchers have now come up with a more pragmatic answer to this question than incorporating the memory-erasing agent as a plot device in a cyberpunk novel

Neuroscientists at McGill University and collaborators have just reported in Molecular Pain that the chemical with the evocative acronym ZIP can selectively wipe out the nervous system’s “memory” of the chronic aches and pains that plague about one in four North Americans, apparently leaving other memories intact.

Pain that persists more than a few minutes leaves a memory trace—that’s why just a light touch is sometimes enough to produce a yelp of agony months after an injury. The archetypal example is the soldier with an amputated leg whose phantom limb still aches years after being severed.

In the experiment at McGill, ZIP administered to the spinal area of rats wiped out pain memories in hind paws that had become tender and hyper-sensitized from the application of capsacin, the compound that produces the burn of chili peppers.

ZIP is the Eternal Sunshine chemical that was spritzed into the memory-forming locus of rat brains to make the animals forget their past. One of the McGill co-authors, Todd C. Sacktor of SUNY Downstate Medical Center in Brooklyn, led the original research that discovered ZIP (zeta inhibitory peptide) along with the memory-preserving enzyme PKM-zeta, which it inhibits.

Years of experimentation and testing would be required to determine exactly where it should be administered to selectively wipe out pain memories without obliterating a lifetime of family recollections. And even then, ZIP will never be an over the counter drug. To be used in medicine, it would need to be injected into the spinal cord to reach the neurons involved with storing the pain memory.

Still, the experiment will leave neuroscientists with a better understanding of the molecular players involved in establishing pain memory. “It gives a clue as to a potential target for influencing persistent and chronic pain,” says Terence J. Coderre, a professor of anesthesiology and neuroscience at McGill who headed the research team.

Even if ZIP never makes its way down the lengthy drug development pipeline, it lays the groundwork for other chemicals that could permanently annul the pain memory that results in the persistent discomfort that turns walking, sitting or even lying down into a daily ordeal for so many.

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Gary Stix, Scientific American's neuroscience and psychology editor, commissions, edits and reports on emerging advances and technologies that have propelled brain science to the forefront of the biological sciences. Developments chronicled in dozens of cover stories, feature articles and news stories, document groundbreaking neuroimaging techniques that reveal what happens in the brain while you are immersed in thought; the arrival of brain implants that alleviate mood disorders like depression; lab-made brains; psychological resilience; meditation; the intricacies of sleep; the new era for psychedelic drugs and artificial intelligence and growing insights leading to an understanding of our conscious selves. Before taking over the neuroscience beat, Stix, as Scientific American's special projects editor, oversaw the magazine's annual single-topic special issues, conceiving of and producing issues on Einstein, Darwin, climate change, nanotechnology and the nature of time. The issue he edited on time won a National Magazine Award. Besides mind and brain coverage, Stix has edited or written cover stories on Wall Street quants, building the world's tallest building, Olympic training methods, molecular electronics, what makes us human and the things you should and should not eat. Stix started a monthly column, Working Knowledge, that gave the reader a peek at the design and function of common technologies, from polygraph machines to Velcro. It eventually became the magazine's Graphic Science column. He also initiated a column on patents and intellectual property and another on the genesis of the ingenious ideas underlying new technologies in fields like electronics and biotechnology. Stix is the author with his wife, Miriam Lacob, of a technology primer called Who Gives a Gigabyte: A Survival Guide to the Technologically Perplexed (John Wiley & Sons, 1999).

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