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Pot joins the fight against Alzheimer's, memory loss

This article was published in Scientific American’s former blog network and reflects the views of the author, not necessarily those of Scientific American


A large-scale study released this week showed that the herb gingko biloba has no effect in preventing dementia or Alzheimer’s disease. But alternative medicine aficionados may find hope in a new research touting the bennies of another "herb" in preserving memory.

Scientists from Ohio State University report that marijuana, contrary to the conventional wisdom,  may help ward off Alzheimer's and keep recall sharp. Their findings, released today at the Society for Neuroscience meeting in Washington D.C.:  chemical components  of marijuana reduce inflammation and stimulate the production of new brain cells, thereby enhancing memory.

The team suggested that a  drug could be formulated that would resemble tetrahydroannibol, or THC, the psychoactive  ingredient in pot sans making the user high. But the research  may ultimately drive those who fear impending dementia to roll their own solution to the problem.

Study co-author Gary Wenk, a professor of psychology, had already devised a preliminary version of a THC-like synthetic drug that improves memory in lab animals. His team at the meeting said that it works by activating at least three receptors in the brain targeted by THC—proteins on the surface of nerve cells  that then trigger cellular processes resulting in reduced inflammation and production of new brain cells that can boost recall. Understanding how the compounds work  may pave the way for a pharmaceutical company to prepare its own  med for human clinical trials.

The researchers ducked the obvious question of whether it might be simpler, faster and cheaper to simply light up a joint. “Could people smoke marijuana to prevent Alzheimer’s disease if the disease is in their family?" Wenk said in a statement. "We’re not saying that, but it might actually work.”

 

 


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Gary Stix, Scientific American's neuroscience and psychology editor, commissions, edits and reports on emerging advances and technologies that have propelled brain science to the forefront of the biological sciences. Developments chronicled in dozens of cover stories, feature articles and news stories, document groundbreaking neuroimaging techniques that reveal what happens in the brain while you are immersed in thought; the arrival of brain implants that alleviate mood disorders like depression; lab-made brains; psychological resilience; meditation; the intricacies of sleep; the new era for psychedelic drugs and artificial intelligence and growing insights leading to an understanding of our conscious selves. Before taking over the neuroscience beat, Stix, as Scientific American's special projects editor, oversaw the magazine's annual single-topic special issues, conceiving of and producing issues on Einstein, Darwin, climate change, nanotechnology and the nature of time. The issue he edited on time won a National Magazine Award. Besides mind and brain coverage, Stix has edited or written cover stories on Wall Street quants, building the world's tallest building, Olympic training methods, molecular electronics, what makes us human and the things you should and should not eat. Stix started a monthly column, Working Knowledge, that gave the reader a peek at the design and function of common technologies, from polygraph machines to Velcro. It eventually became the magazine's Graphic Science column. He also initiated a column on patents and intellectual property and another on the genesis of the ingenious ideas underlying new technologies in fields like electronics and biotechnology. Stix is the author with his wife, Miriam Lacob, of a technology primer called Who Gives a Gigabyte: A Survival Guide to the Technologically Perplexed (John Wiley & Sons, 1999).

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