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Posts Tagged "drug development"

Molecules to Medicine

Ebola and Priorities in Drug Development

Ebola in Guinea (flickr Euro Comm DG ECHO)

News is rapidly changing regarding Ebola. Even as I’ve been writing this post, we’ve gone from “There is no treatment except supportive care” to NIH’s Dr. Fauci saying a potential vaccine “could be given to health workers in affected African countries sometime in 2015.”⁠ This optimistic projection was a surprise to me, as normally it [...]

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Molecules to Medicine

What do you need to know to survive this year’s flu?

I spent a year filtering spit and nasal washings, growing influenza in tissue cultures in a minimalist lab, and trying to develop an oral flu vaccine, all as part of my Infectious Diseases fellowship thirty years ago. We’re still not there…but for now, here is information to help you this year. Every year, the strains [...]

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Molecules to Medicine

The Checklist Manifesto Meets Clinical Trials–SPIRIT13

ClinicalTrials.gov

ClinicalTrials.gov Atul Gawande has made human lapses more understandable, if not acceptable, reminding us that “We miss stuff. We are inconsistent and unreliable because of the complexity of care,” and making the idea of checklists mainstream, rather than a prop for failing memories. One of the difficulties for any new researcher—and some experienced ones—is designing [...]

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Molecules to Medicine

Antibiotic resistance-another view from the trenches

Remember the story of the elephant and the blind men? I feel I am revisiting it whenever I go back and work another stretch in the hospital as an infectious diseases physician. There are great articles giving a broad overview of the rise in antibiotic resistant organisms, especially Carbapenem resistant enterobacter, written by Maryn McKenna, [...]

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Molecules to Medicine

Covering Clinical Trials: a message for journalists and critical readers

Linnea Duff shows off her "famous lungs" at #ahcj13

My message: Ask the hard questions. The Association of Health Care Journalists annual conference (#ahcj13) covered a variety of topics, with lectures and panels followed by question and answer sessions. As with many conferences, it was tough to choose between competing sessions. I learned a great deal about health care, databases, and resources to help [...]

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Molecules to Medicine

From the Holocaust to Thalidomide: A Nazi Legacy

I was attending World Federation of Jewish Child Survivors of the Holocaust and Descendants 24th Annual International Conference in Cleveland last week, when my aunt, herself a survivor, handed me a copy of Newsweek with a cover article, “The Nazis and Thalidomide: The Worst Drug Scandal of All Time.” The story was prompted by the [...]

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Molecules to Medicine

A Glut of Obesity Drugs?

On June 27, the FDA approved the first new weight-loss drug in 13 years, Arena’s lorcaserin (Belviq). The track record for anti-obesity drugs has not been very good—each has been withdrawn from the market, after approval, due to safety concerns. Why was this drug approved? How long will this one last before being yanked for [...]

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Molecules to Medicine

Clinical Trials for Beginners: Recipe for a new drug

Sometimes it seems like new drugs suddenly appear like magic. Have you ever wondered if there was something special going on behind the scenes? Earlier in Clinical Trials for Beginners, we looked briefly at why drug studies came into being, then at how a drug is developed, from test tube to your tissues. Let’s take [...]

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Molecules to Medicine

Welcome to Molecules to Medicine!

I’m Dr. Judy Stone, an infectious diseases physician and author. I love helping people understand issues and look at things from a different perspective. I hope I can offer you some different insights—bridging the gap between basic science and your medicine chest—as I am still a practicing physician, as well as having had broad clinical [...]

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Molecules to Medicine

Molecules to Medicine: From Test-Tube to Medicine Chest

We looked briefly at why drug studies came into being; now let’s look at how a drug is developed, from test tube to your tissues. Every government approved drug goes through the same sequence of testing anywhere in the world. In the US, this is done under the supervision of the FDA, and is conducted [...]

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Talking back

Ketamine, a Darling of the Club Scene, Inspires Development of Next-Generation Antidepressants, Part 3

Recent experimental research showing that the anesthetic and club drug ketamine can relieve depression quickly has intrigued a number of major pharmaceutical companies. Depression, it goes without saying, affects huge numbers and a fundamentally new and effective pharmaceutical approach to treating the disorder hasn’t emerged in decades. The enthusiasm for ketamine is such that physicians, [...]

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