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The Search for a Nobel Prize-Winning Synapse Machine

In the cellular machinery that Rothman, Schekman and Südhof all helped reconstruct, a SNARE complex - made of synaptobrevin, syntaxin and SNAP-25 - zips together to bind a synaptic vesicle to the surface of a receiving neuron. Courtesy of Danko Dimchev Georgiev, M.D. via Wikimedia Commons.

2013’s Nobel prize in Physiology or Medicine honors three researchers in particular – but what it really honors is thirty-plus years of work not only from them, but also from their labs, their graduate students and their collaborators. Winners James Rothman, Randy Schekman and Thomas Südhof all helped assemble our current picture of the cellular [...]

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