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Lab Rat

Lab Rat


Exploring the life and times of bacteria
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    S.E. Gould A biochemist with a love of microbiology, the Lab Rat enjoys exploring, reading about and writing about bacteria. Having finally managed to tear herself away from university, she now works for a small company in Cambridge where she turns data into manageable words and awesome graphs. Follow on Twitter @labratting.
  • Blogroll

  • Butterfly watch: multi-generational migrations

    The Painted Lady butterfly, Vanessa cardui. Picture taken in Ename, Belgium Tim Bekaert (July 12, 2005).

    Migrating animals are always impressive to watch. The ability to cover huge areas of land in massive groups can be a beneficial strategy for many animals; whether birds, mammals or shoals of fish. Yet even more impressive than migrations by groups of individuals are those that take place over several generations. In the case of [...]

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    How to eat your host: Pathways for nutrition in Salmonella

    Salmonella typhimurium. Photo: Volker Brinkmann, Max Planck Institute for Infection Biology, Berlin, Germany. Image from reference 2.

    From the point of view of an intracellular bacteria, the human body really is no more than just a habitat in which they must grow and thrive. While this particular habitat might have stable internal conditions, and less competition than the big open world, it has its disadvantages in continuous attacks from the immune system, and the [...]

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    Lab Rat has a baby on board!

    scan 12 weeks

    It has been a while since I’ve last posted. Usually I try not to give excuses for lateness, but this time I do have a very good one. I’m currently 15 and a half weeks pregnant! In the UK there is a fairly good and well thought-out system to make sure pregnant women get all [...]

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    The Carnival of Evolution: World Travel Edition!

    800px-African_passport_stamps

    Welcome to the 56th edition of the Carnival of Evolution. I haven’t been on holiday for a while, so for this issue I thought I’d take a trip around the world, looking in on all the exciting research and work being done in the field of evolution. There are some great posts here, from some [...]

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    The bacteria that use cholesterol to get into cells.

    Diagram of the membrane that surrounds human cells. The two layers of phospholipids can be seen (blue and while spheres with the lipid tails pointing inwards) studded with bright red proteins. The yellow blobs within the phospholipid layer are cholesterol.

    Although it usually only gets talked about when it starts causing problems, cholesterol is an important molecule to have in the body, as it is a component of cell membranes. The major component of cell membranes is a molecule called a phospholipid; an inorganic phosphate molecule joined onto lipid tails. Lots of these phospholipids all [...]

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    Making sugar from carbon dioxide: The Calvin Cycle

    Leaf_1_web

    The process of photosynthesis is often described as turning sunlight into sugars, and while that’s broadly true, there are two distinct biochemical reactions taking place. The first uses the sunlight to create energy inside the cell and the second takes carbon dioxide and uses it to make sugars. The second is the Calvin cycle although [...]

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    Toxic Little Molecules

    The rod shaped Clostridium Difficile bacteria, image from the  Centers for Disease Control and Prevention, part of the United States Department of Health and Human Services.

    There are various different ways that pathogenic bacteria can damage and kill human cells, but one of the most common is by the production of toxic molecules. These small molecules are made inside the bacterial cell, the protein chain built using the DNA template and then often modified within the cell before being secreted directly [...]

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    Not all biofilms are equal: The hyper-biofilm of P. aeruginosa

    P. Aeruginosa from wikimedia commons.

    December turned out to be a rather hectic month for several reasons, so I decided to take a break from blogging. Now the holidays are over, I will back to regular blogging for 2013! In a previous post I wrote about how two-component systems evolved in bacteria while dying out in animals, so for this [...]

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    What makes things acid: The pH scale

    The pH scale, with a list of substances at each pH. Image credit below.

    I remember learning about acids and bases (or acids and alkalis) fairly early on at school. Acids were sharp vinegary substances like lemon juice, while alkalis were soapy substances, like limewater or caustic soda. We also learnt about the pH scale which measures the acidity or alkalinity of a substance. The pH scale goes from 1-14, [...]

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    How the animals lost their sensors

    The components of the two-component signalling system. Picture (c) me.

    For free-living organisms, the ability to sense and respond to the outside environment is crucial for survival. Eukaryotes, such as animals and plants, often have highly complex network systems in place to monitor their surroundings and respond effectively, but bacteria have developed a remarkably simple system. It’s called the ‘Two Component System’ because it literally [...]

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