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Posts Tagged "tumors"

Guest Blog

Hallmarks of Cancer 8: Tumor-Promoting Inflammation

Tumors and their TAMs. Tumors secrete signalling molecules known as chemokines to attract circulating monocytes, a type of white blood cell. Once in the tumor, the monocytes differentiate into Tumor Associated Macrophages (TAMs). Oxygen-starved (hypoxic) areas of the tumor secrete VEGF, which attracts these TAMs. TAMs can also secrete VEGF, which in turn attract more TAMs to the tumor. / Image by Buddhini Samarasinghe.

The Hallmarks of Cancer are ten underlying principles shared by all cancers. You can read the first seven Hallmarks of Cancer articles here. The eighth Hallmark of Cancer is defined as “tumor-promoting inflammation.” We consider the immune system as our friend; it protects us by fighting infections while keeping us healthy. But there is a [...]

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Guest Blog

Hallmarks of Cancer 6: Tissue Invasion and Metastasis

The Hallmarks of Cancer are 10 underlying principles shared by all cancers. You can read the first five Hallmarks of Cancer articles here. The Sixth Hallmark of Cancer is defined as “Tissue Invasion and Metastasis.” A growing tumor will eventually spawn pioneer cells; these move out of the original clump of mutant cells to invade [...]

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Observations

What Do Your Tumor Genes Say about Your Prospects? The Quest, Part 7

In the past couple of months, three people have told me that they or someone they love has cancer. Fortunately in each case, the tumors were caught early and some combination of surgery and radiation was all the treatment that was likely to be needed. Now, however, all three patients are waiting to hear what [...]

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