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There Should Be Grandeur: Basic Science in the Shadow of the Sequester

The views expressed are those of the author and are not necessarily those of Scientific American.

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Just before any predictable disaster hits, it’s almost impossible to take even a medium term view.  With the sequester bearing down on us in a couple of days, identifying the immediate consequences is terrifying enough.  Just check out the Obama administration’s state-by-state list of the grim weeks ahead.

The picture derived from that tally is evil enough, as we all (or should) know by now. In broad strokes, it will slow the recovery, cut economic growth, and act as a persistent drag on ordinary folks’ attempts to make a better life — hell, to pay the rent on the first of the month.  But there is a sense, I think, that however crappy conditions may get for the weeks or months before some resolution emerges, matters will return to normal in reasonably short order.

But that’s wrong, at least when it comes to the future of science in the United States.  The federal government is by far the lead funder for basic scientific research. [PDF; see p. 5]  When the funding stream dries up, even briefly, work doesn’t just pause for a bit; instead, the blow cuts deeper, past fat, through muscle and into bone.  There’s been some coverage of this over the last week or so.  For example, in an interview conducted by Dylan Matthews, former NIH director Elias Zerhouni said:

“I think the suddenness of it and the depth of it would be a disaster for research, which is not an activity that you can turn on and off from year to year. It’s an activity that takes time. The most   impacted  are the young, new investigator scientists, who are coming into science, and will now abandon the field of science. There will be a generational gap created.

An average grant is five  years long, because science is like that. So think: That means that every one year, only 20 percent of the grants come to their end. So any one year, NIH only has 20 percent  of its money available for new grants. At NIH, about half of the grants get terminated at five years, but the rest get to be continued, as you don’t want to throw away good research. So the half of it that’s left has to go to very promising areas of science, and you have 10 percent left.

If you take 8 percent of that 10 percent, it’s going to come from new science, new people, young investigators; we are going to maim our innovation capabilities if you do these abrupt deep cuts at  NIH. It will  impact science for generations to come.”

“New science, new people, young investigators.”  That’s the rub.  But the issue involves more than the sequester itself.  Rather, for at least a large slice of the basic research community, the killing force of the current plan comes from the way it piles on to an already ailing enterprise.  Last week I contacted my colleague, Marc Kastner, a physicist, former head of the physics department, and now Dean of the School of Science at MIT — which makes him the leader of a some-hundreds of million dollars/year basic research enterprise.  The story he told me ain’t pretty.

For MIT itself the effects, Kastner says, will hurt — a lot.  The hit to the annual research budget will be about $40 million — falling most heavily on the School of Science, which gets 95% of its research budget from the federal government.  The effects won’t be felt equally across the board.  If you run a big lab then you have some room to manouver, Kastner acknowledges.  “Is ever Eric Lander going to slow down? He’ll find a way.”  But, he says, “The rich survive and the poor get devastated.  The real question is the next generation. ”

That is: the sequester wreaks its havoc by striking hardest at particular points in the life cycle of a university researcher.  New tenure-line faculty are actually somewhat insulated from the very worst of the pressure.  “Every agency has set aside money for young investigators,” he says,”some from private foundations, and a lot from the feds.”  Cuts in budget strike those dependent on other people’s grants — graduate students, post docs and soft-money research scientists — but a new faculty hire has somewhat better prospects than most for the first few years.

The rubber hits the road, though, at tenure.  MIT, like other leading research universities, generally tenures faculty at around the seven year mark.  Researchers achieve tenure on the basis of strong performance in those first years and then after promotion are expected to advance their program through what should be the heart of their productive lives.  The tricky part is that it is already enormously difficult to do so.  Once tenured, the researcher competes for grants against the entire population, Nobel laureates, National Academicians and all.  There’s a reason that the average age for winning your first R0-1 grant is 42 — that’s up by more than five years since 1980.  Add the sequester’s cut on top of that existing semi (or more than)-crisis, and you have a circumstance where early-mid career scientists could become even more at risk to career-blasting loss of research funding.

So, add that up:  sequester cuts will strike bluntly across the scientific community.  The illustrious can move a bit of money around, but even in large labs, a predictable result will be a reduction in the number of graduate student and post – doc slots available — and as those junior and early-stage researchers do a whole lot of the at-the-bench level research, such cuts will have an immediate effect on research productivity.

The longer term risk is obvious too:  fewer students and post-docs mean on an ongoing drop from baseline in the amount of work to be done year over year, and given that industry has reduced its demand for research-trained Ph.Ds, a plausible consequence is that some, many perhaps, those with capacity to do leading edge science — no dummies they — will simply never enter the pipeline, shifting instead to some other career that does not demand six years and more of poorly paid training to find that there are no jobs.

But that mid-career trap is at least as troubling:  By the time you have a scientist who has done well enough to earn tenure at a research institution, someone — the taxpayer, to a very large extent — has invested a ton of money, often well into seven figures, into her training and early professional life.  If she ends up without that crucial next grant, that money is at risk. The work we’ve all been paying for doesn’t come to a conclusion, and, if our brilliant, mid-thirties investigator finds something else to do, all her time and all that cash are sunk costs, irrecoverable even if Congress relaxes the sequester’s bite after a while.

The immediate situation is thus one in which the overall research effort in basic science in the US risks a loss of talent from at least two inflection points in the normal course of a research career.  But that’s not all.  In Kastner’s genuinely grim account, a certain heedlessness in our leading research institutions, especially among those who’ve gone all-in on biomedical work, is going to make the problem worse.  Over the last several years NIH budgets have doubled, allowing more basic biology and applied bio-medical researchers to get in the game. 

Institutions have grabbed the opportunity, and because of the rules about what you can actually charge against overhead on research grants, some borrowed money to build the very expensive buildings in which such work is done.  Servicing the loans turns on filling the lab space with grant-getting researchers; the imperative is so stringent that you hear charming phrases like the “dollar density” of research. (Those researchers insufficiently cash dense get squeezed of space, stuffed into basements and the like.)

The whole scheme turns on continued substantial NIH budget growth.  Factor in the sequester — and you can bet that there are a number of institutions for whom loss of grants will have a multiplier effect, because of the need to find new cash to pay for debt service on underutilized space.  Less institutional cushion means still fewer resources for students and post docs; it limits the possibilities of new hires and so on — and the numbers continue to roll in the wrong direction.

Now add one more datum.  If you look at the history of US funding [pdf, fig. 2, p. 5] for science over the last fifty years, you see that with the exception of the Apollo years, it remained more or less constant as a percentage of GDP to the 1980s, after which it has experienced a slow decline.  Looking at the federal budget going forward, the reality is that as long as health care spending looks to consume its increasing share of both GDP and national budgets, then basic science, like everything else in the federal discretionary budget, is going to remain under pressure.  Thus, even without the sequester, there is no shower of gold ready to rain down on the research community.

In that larger frame, Kastner argues, we are now confronting a problem that’s been mounting for decades.  The meat-axe poised over the biological sciences struck his own field of physics back in the seventies:  “That was when you heard about theoretical physicists driving cabs.”  The response?  “Groups got smaller and post-docs got treated better.” (Sic! Even now, physics post docs at national labs get significantly higher pay than new Ph.D post docs in biology, Kastner says.)  Something similar is likely in prospect now:  “Maybe what we need is simply to have fewer graduate students.” The issue, brought into focus by the battle over the sequester is that for any of the gambles individual centers may have chanced, ultimately the decision about how much science the U.S. chooses to pursue is a civic one. Right now, Kastner says, “we have over-produced scientists given the investment we are willing to make as a society.”

In sum: “the reality is that I think the sequester will have a rolling effect on science research” Kastner says, “but it’s hard to tell as there are no controls.”  Thinking parochially for a moment, MIT and similarly well-off, internationally recognized universities will hold up. Not perfectly, not without pain, but still, they’ll persist. And certainly, science as a human enterprise isn’t going to go away.   But that’s not the same thing as saying that America’s scientific pre-eminence is invulnerable. “There are places around the world which will fill the gap,” Kastner tells me as our conversation winds down. They’re just not necessarily here in the U.S.

That’s one view, acquired from the vantage of the leader of one of the world’s most effective basic research centers.  Let me add one more thought from my own, much more modest perch.

It’s easy and usually foolish to spin narratives of decline out of a momentary political circumstance.   It is true now and looks to remain so for the foreseeable future that the U.S. retains its slot atop the national league tables on all kinds of different measures of power.  If the gap between us and the rest of the world is shrinking, compared to the extraordinary circumstances of the post-World War II era, that’s a very good thing: it means that the rest of the world is getting richer, healthier, more comfortable.

But that doesn’t mean that it is impossible to imagine an actual decline in U.S. power and independence of action.

There are lots of reasons to do science.  The one you hear most often, I think, is that human beings are obligately curious.  You can make the claim we emerged from our evolutionary past to produce our science-infused civilization because of some confluence of traits that included the willingness to accept risk in the face of the unknown, to ask questions.That has the ring of plausibility to me. You don’t become a parent without discovering in your child that drive to find things out.

Then there’s the aesthetic quality to science.  There’s so much beauty to be found in the systematic investigation of nature — from the grandeur of Darwin’s tangled bank to the iconic force of the Hubble Space Telescope’s “Pillars of Creation” image, made by Jeff Hester and colleagues and on and on and on.

Add to that the simple satisfaction that comes from solving puzzles — a reward that motivates more scientists than I first imagined, and that I think may also drive much of the public’s hunger for stories of science that one might write with that scientific detective, Sherlock Holmes, perched at the back of one’s mind.

But to cut through to the hard cash at the core of this whole crisis, the simple truth is that paying for basic research is a bet a society makes on its future.  And it turns out that it is one of the safest wagers around.  In the 2007 report linked above, the CBO writes, in predictably dry language, “Federal spending in support of basic research over the years has, on average, had a significantly positive return, according to the best available research.” (p. 15)  Or, to put it a more gaudily, it’s estimated that the Human Genome Project delivered a return on investment of 141:1 — $141 in wealth created for every dollar spent on the job.

No one claims that all basic research posts such glorious rewards, but as MIT president Rafael Reif and former Intel CEO Craig Barrett noted this week in the Financial Times, “A report by the non-partisan Information Technology & Innovation Foundation estimates that over those nine years, such cuts would reduce GDP by $200bn – and that estimate compares sequestration to a scenario where R&D merely remains at the 2011 rate. If in those nine years the US instead kept R&D spending constant as a proportion of output, the economy would be $565bn bigger. And if it invested in R&D at the same rate as China, that gap would grow to $860bn.”

Thus the risk posed by the sequester: it magnifies strains in an already constrained scientific enterprise.  And from that, it’s not hard to weigh the concept of decline, an actual, lasting erosion of essential national capacity.  We can certainly avoid such an unforced error; we can decide to invest more, and more reliably in the future.  But we may not…and that choice has consequences that aren’t too difficult to perceive.

Image: Rembrandt van Rijn, The Anatomy Lesson of Dr. Tulp, 1632.

Tom Levenson About the Author: Tom Levenson's day job finds him at MIT, where he is a Professor of Science Writing. He writes books, most recently Newton and the Counterfeiter, about the collision between the greatest thinker of the scientific revolution, crime, and the birth of the modern idea of money. He also makes documentary films, which have appeared on the PBS series NOVA, the BBC series Horizon, and in many other venues. He loves the insight history brings to science writing -- and is very happy that we create new material at a rate of one day's worth per day. Follow on Twitter @TomLevenson.

The views expressed are those of the author and are not necessarily those of Scientific American.

Comments 12 Comments

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  1. 1. rodestar99 7:57 am 02/28/2013

    And just what do you think will happen to research if
    we continue down the current deficit path until we get to the condition of Greece.
    We need to use the available money smarter.
    Climate research is a prime example. This field is
    populated with pseudo scientists who are studying something we can do nothing about and putting a drag on
    the whole economy by diverting resources from areas
    that could better benefit us all and driving jobs and
    investment overseas.

    Link to this
  2. 2. Paleoecologist 9:57 am 02/28/2013

    “New tenure-line faculty are actually somewhat insulated from the very worst of the pressure.”

    I want to push back against this a little. It’s something I hear commonly, but at least in some divisions of NSF, when you look at the numbers, new folks aren’t getting funded at a greater rate (NIH may be different). As numbers are coming out from DEB, for example, which just switched to one proposal cycle a year (instead of two) and limits your proposals to two, early-career PI’s did as (or slightly) less well as the funding rate average. Therefore I have half the chances to get a grant funded in hte next six years, and lower odds each time. As a new faculty starting this fall (who put in two proposals this year out of concern for funding rates), I don’t feel especially cushioned. And in my case, my job security is tied to that money. If a tenured PI doesn’t pull in grant money, the repercussions are much less.

    Meanwhile, of course, science suffers across the board.

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  3. 3. sjfone 12:05 pm 02/28/2013

    Just so they keep the athletic scholarships and the coaches salaries.

    Link to this
  4. 4. RSweeney 4:58 pm 02/28/2013

    This year, the Federal government will borrow ANOTHER $1 TRILLION for our children to pay back.
    That’s in addition to the $16 TRILLION already borrowed ($6 Trillion of that in the previous 4 years of this administration). That’s in addition to the tens of trillions our children will be forced to pay for Social Security, Medicare, public pensions and all the rest of the stuff that we have borrowed for them to pay.

    Sorry folks, asking you to drop 5% of the budget is not a problem, it’s just a down payment on the cuts to come.

    We simply can not afford the nice-to-haves when got-to-haves are threatened.

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  5. 5. Quantumburrito 5:26 pm 02/28/2013

    Scientific research is not a “nice to have”, it’s a “got to have”.

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  6. 6. cataplexis 6:33 pm 02/28/2013

    Why do so many T-baggers compare the US to Greece? Do they really think that the world’s most powerful economy compares so easily to a third-world tourist destination? Here’s the analogy for you supposedly fiscally conservative types:

    An executive pulling down $15T per year takes out a loan to buy a house worth $16T. She’s fallen on a tough spot, and so her household expenses exceed her income by $1T (6.7%). However, she knows that the tough spot is temporary and by continuing to invest in her business, her future revenues and thus income will surpass and pay for the deficit. Her bankers believe her so they extend her loans.

    Now compare that with the plumber pulling down $0.3T per year (or 1/50th of the exec’s income). This person takes out a loan to buy a house worth $0.4T. He’s also going through a rough spot, and his household expenses by $0.036T (12%). No one believes he’s capable of paying his loans or covering his expenses any time soon, so the bankers and relatives who loaned him money, they all shut him off and demand he live more frugally.

    Now, the executive’s 5 year old kid learns from his kindergarten friends that the plumber across town is having money troubles, and comes home yelling at his mom that she’s acting just like the plumber.


    How many of you fiscally conservative T-baggers have taken out loans many times your annual income – your home mortgage? On top of your car loans. On top of your credit card debt. I know there was no school debt for you folks. And you yell when the government manages well below your debt levels?

    Grow up – learn to look at numbers before making silly comparisons.

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  7. 7. ex0du5 7:44 pm 02/28/2013

    @rodestar99 and @RSweeney:

    The total federal outlay and the per-capita federal outlay have actually decreased under Obama ( They also did so under Clinton (at least per-capita), but not as drastically.

    The most fiscally conservative policy one could hope for is to have a single payer health care system, as amortised risk would be minimised (and it would eliminate middle man markup on the zero-benefit insurance system) and the largest federal outlay would be cut the most.

    So.. if things stay the same as they have under Obama, we will have a balanced budget in 10 years. And if you want to make that go faster, we could expand Obamacare to single payer as originally intended.

    Could you explain why cuts are needed to the science grant system?

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  8. 8. Steve D 10:07 pm 02/28/2013

    Not only need science not suffer, we can actually improve funding dramatically. How? Fund only science.
    1. No overhead charges. It’s the institution’s job to keep the lights lit.
    2. No fringe. You hired ‘em, you pay their fringe benefits.
    3. No page charges. No publication in for-profit journals and all research is published in the public domain.
    4. No investigator salaries. If you believe research is essential to graduate schools, pay your investigators to do it.
    1 and 2 would probably triple the amounts available for real science. Typically 25% or more of the grant amount is tacked on for fringe, and 50% or more of THAT is tacked on for overhead.

    Link to this
  9. 9. dubina 4:27 am 03/1/2013

    Even now, physics post docs at national labs get significantly higher pay than new Ph.D post docs in biology, Kastner says.) Something similar is likely in prospect now: “Maybe what we need is simply to have fewer graduate students.”

    The issue, brought into focus by the battle over the sequester is that for any of the gambles individual centers may have chanced, ultimately the decision about how much science the U.S. chooses to pursue is a civic one. Right now, Kastner says, “we have over-produced scientists given the investment we are willing to make as a society.”

    Quite so.

    The sequester is a drop in the bucket of Federal budget deficit reduction.

    The Federal budget deficit is due to our collective appetite for “things” that we cannot have or do as individuals or companies of individuals. We all want our own special things and could do without most of the special things wanted by others. We have created this false economy of things and special interest advantages over time, decades and more.

    Many things that we do and have are self-serving and wasteful. Science and what passes for education these days are not exempt. DARPA, for example, funds the Hundred Year Starship Project. What nonsense! NASA is not exempt. Who cares if Mars once supported microbial life. It’s barren now. What is the point in so many cases now but science for the sake of science? Science is awash in bogus issues and causes. I have been scandalized by some of the research topics that pass muster for federal grants.

    It is a poor reflection of our 2013 democracy that law-makers cannot survey their revenue generators and spending decisions and make rational choices about what to leave in and what to leave out. Suffice it to say our democracy is corrupt that way. It is a shameful thing that we will now resort to across-the-board spending cuts. More cuts will be needed.

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  10. 10. kienhua68 2:22 pm 03/1/2013

    All the panic for essentially nothing. The most important aspects of research will continue. I believe most of this
    is generated by story more than fact.
    This may be the perfect time to reevaluate present research trends to best utilize remaining funds.
    Let us take this challenge to delineate real research from that which exists only to create a job.
    I call it the desert island scenario.

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  11. 11. Hydronium Hydroxide 1:18 pm 03/2/2013

    @cataplexis, your comparison is fallacious. We are already out of the “reccesion.” We are taking in much more in taxes than we did throughout the so called “boom years.” And even then we were spending more than we were taking in. You see when I take out massive loans, I have a plan to pay them back. The government doesn’t. It just plans to give more free crap to stupid people and hope beyond hope that they somehow use that money for good, even when the studies show such programs to have no effect, as they have done with Head Start. And if they mismanage themselves, it is the taxpayer who has to pay for it. As for the creditors trusting the gov, are you aware of the downgrade? They have been pretty clear that unless we make cuts somehow, they will downgrade us further.

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  12. 12. cataplexis 8:23 pm 03/3/2013


    Let’s start from your last comment:
    ” As for the creditors trusting the gov, are you aware of the downgrade? They have been pretty clear that unless we make cuts somehow, they will downgrade us further.”
    Have you noticed that after the housing debacle no one pays attention to S&P, Moody’s or Fitch? The downgrade had no effect on the lending rates the US govt has to pay. Again, very different from Greece. The point is, there is no comparing the US to Greece.

    “You see when I take out massive loans, I have a plan to pay them back.”
    When I see you on the street with a tin cup, I’ll remember that… Statistics demonstrate clearly that the vast majority of individuals who take out massive loans are not able to handle the payments and manage the risks intelligently – and I doubt you will do any better.

    “The government…just plans to give more free crap to stupid people and hope …that they somehow use that money for good”
    You call people without jobs or in low income jobs stupid? I’m afraid you’ve just placed yourself into your own category. What is the single largest segment of our economy? Consumer spending at over 2/3 of GDP. When a govt provides temporary assistance to low/no income people during hard times, where does that money go? Directly into the economy to buy things. When govts provide tax relief to the wealthy, where does that money go? Into investment accounts where it does no one any good.

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